Hypoglycemic action of 2-aminonorbornane-2-carboxylic acid in the rat
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منابع مشابه
Hypoglycemic action of 2-aminonorbornane-2-carboxylic acid in the rat.
Correct orientation of the amino and carboxyl groups and of the bicyclic ring of the compound 2-aminonorbornane-2-carboxylic acid is essential for its induction of a tolbutamide-potentiated hypoglycemia in the rat, an effect which we have already shownto arise from stimulation of insulin release. Only that isomer with its carboxyl group ~xo and the absolute configuration 12, 2S, 4S has this act...
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Barium salts of dibenzylidene cystines 8a-c were obtained from the reaction of Lcystine with benzaldehyde or its derivatives in the presence of barium hydroxide. Their reduction with zinc and hydrochloric acid in methanol yielded the Narylmethylcysteines ?9a-c?. These can, in turn, be converted by esterification into the methyl esters ?10 a-c. ?Reaction of N, N'-carbonyl diimidazole (Im C...
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The crystal structure of the title compound, C(10)H(6)ClNO(2), can be described by two types of crossed layers which are parallel to (110) and (10). The crystal packing is stabilized by inter-molecular C-H⋯O and O-H⋯N hydrogen bonds, resulting in the formation of a two-dimensional network and reinforcing the cohesion of the structure.
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In the title compound, C(5)H(5)NO(2), the pyrrole ring and its carboxyl substituent are close to coplanar, with a dihedral angle of 11.7 (3)° between the planes. In the crystal structure, adjacent mol-ecules are linked by pairs of O-H⋯O hydrogen bonds to form inversion dimers. Additional N-H⋯O hydrogen bonds link these dimers into chains extending along the a axis.
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 1971
ISSN: 0006-291X
DOI: 10.1016/s0006-291x(71)80176-6